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Chemical Structure
Chemical Structure
Chemical Structure

CC-401 hydrochloride

SYN-1028
SYNkinase
CAS Number395104-30-0
Product group Chemicals
Estimated Purity>95%
Molecular Weight388.4 . 36.5
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Overview

  • Supplier
    SYNkinase
  • Product Name
    CC-401 hydrochloride [1438391-30-0, 395104-30-0]
  • Delivery Days Customer
    10
  • CAS Number
    395104-30-0
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C22H24N6O . HCl
  • Molecular Weight
    388.4 . 36.5
  • Scientific Description
    CC-401 is a competitive inhibitor of the ATP binding site in the active, phosphorylated, form of JNK. This prevents JNK from phosphorylating its various target molecules, including the amino terminus of c-Jun. It is a potent inhibitor of all three forms of JNK (Ki of 25-50 nM), and has at least 40-fold selectivity for JNK compared with other related kinases, including: p38, ERK, IKK2, PKC, Lck, and ZAP70. CC-401 acts to inhibit JNK signaling by competitive binding to the adenosine triphosphate-binding site in the active, phosphorylated, form of JNK, resulting in inhibition of the phosphorylation of JNK targets, such as the amino-terminal activation domain of the transcription factor, c-Jun. In cell-based assays, 1-5 muM CC-401 provides specific JNK inhibition. - Chemical. CAS: 1438391-30-0. Formula: C22H24N6O . HCl. MW: 388.4 . 36.5. CC-401 is a competitive inhibitor of the ATP binding site in the active, phosphorylated, form of JNK. This prevents JNK from phosphorylating its various target molecules, including the amino terminus of c-Jun. It is a potent inhibitor of all three forms of JNK (Ki of 25-50 nM), and has at least 40-fold selectivity for JNK compared with other related kinases, including: p38, ERK, IKK2, PKC, Lck, and ZAP70. CC-401 acts to inhibit JNK signaling by competitive binding to the adenosine triphosphate-binding site in the active, phosphorylated, form of JNK, resulting in inhibition of the phosphorylation of JNK targets, such as the amino-terminal activation domain of the transcription factor, c-Jun. In cell-based assays, 1-5 muM CC-401 provides specific JNK inhibition.
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    51202000

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