CCG-50014

MedChem Express

CCG-50014 [883050-24-6]

10

883050-24-6

Research Use Only

99.42

C16H13FN2O2S

316.35

CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) ( IC 50 =30 nM) and is >20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site [1] . CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test [2] .

O=C(N1CC2=CC=C(F)C=C2)N(C3=CC=C(C)C=C3)SC1=O

-20°C,2°C to 8°C

12352200