CCG-50014 [883050-24-6]

Biorbyt

CCG-50014 [883050-24-6]

16

883050-24-6

Research Use Only

C16H13FN2O2S

316.35

CCG-50014 is the most potent against the regulator of G-protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is > 20-fold selective for RGS4 over other RGS proteins. CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG50014, reduces nociceptive responses and enhances opioid-mediated analgesic effects in the mouse formalin test.

FC1C=CC(CN2C(=O)SN(C3C=CC(C)=CC=3)C2=O)=CC=1

12352200