CCM2 Polyclonal Antibody

Reddot Biotech

CCM2 Polyclonal Antibody

5

ImmunoHistoChemistry

Research Use Only

1 mg/ml

Unconjugated

CCM2

CCM2 scaffold protein

C7orf22; CCM2 scaffolding protein; cerebral cavernous malformation 2; cerebral cavernous malformations 2 protein; malcavernin; OSM; osmosensing scaffold for MEKK3; PP10187

Rabbit

IgG

This gene encodes a scaffold protein that functions in the stress-activated p38 Mitogen-activated protein kinase (MAPK) signaling cascade. The protein interacts with SMAD specific E3 ubiquitin protein ligase 1 (also known as SMURF1) via a phosphotyrosine binding domain to promote RhoA degradation. The protein is required for normal cytoskeletal structure, cell-cell interactions, and lumen formation in endothelial cells. Mutations in this gene result in cerebral cavernous malformations. Multiple transcript variants encoding different isoforms have been found for this gene.

Human, Mouse, Rat

-20°C

12352203