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ProductsBack/CCND1 Recombinant Monoclonal Antibody
Western Blot Positive WB detected in: NIH/3T3 whole cell lysate, SH-SY5Y whole cell lysate, U-87 whole cell lysate All lanes: Cyclin D1 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 34 kDa Observed band size: 34 kDa
Western Blot Positive WB detected in: NIH/3T3 whole cell lysate, SH-SY5Y whole cell lysate, U-87 whole cell lysate All lanes: Cyclin D1 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 34 kDa Observed band size: 34 kDa
Western Blot Positive WB detected in: NIH/3T3 whole cell lysate, SH-SY5Y whole cell lysate, U-87 whole cell lysate All lanes: Cyclin D1 antibody at 1:1000 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 34 kDa Observed band size: 34 kDa

CCND1 Recombinant Monoclonal Antibody

CSB-RA616025A0HU
Cusabio
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman, Mouse
TargetCCND1
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Overview

  • Supplier
    Cusabio
  • Product Name
    CCND1 Recombinant Monoclonal Antibody
  • Delivery Days Customer
    20
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    5D8
  • Conjugate
    Unconjugated
  • Gene ID595
  • Target name
    CCND1
  • Target description
    cyclin D1
  • Target synonyms
    B-cell CLL/lymphoma 1; B-cell lymphoma 1 protein; BCL1; BCL-1 oncogene; D11S287E; G1/S-specific cyclin-D1; PRAD1; PRAD1 oncogene; U21B31
  • Isotype
    IgG
  • Protein IDP24385
  • Protein Name
    G1/S-specific cyclin-D1
  • Scientific Description
    Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D1/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex. Exhibits transcriptional corepressor activity with INSM1 on the NEUROD1 and INS promoters in a cell cycle-independent manner.
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203