CCND3 antibody
ORB107017
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetCCND3
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Overview
- SupplierBiorbyt
- Product NameCCND3 antibody
- Delivery Days Customer16
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- Applications SupplierWB: 1:1000 IHC-P, WB
- CertificationResearch Use Only
- ClonalityPolyclonal
- Clone IDRB43029
- ConjugateUnconjugated
- Gene ID896
- Target nameCCND3
- Target descriptioncyclin D3
- Target synonymsD3-type cyclin; G1/S-specific cyclin-D3
- HostRabbit
- IsotypeIgG
- Protein IDP30281
- Protein NameG1/S-specific cyclin-D3
- Scientific DescriptionRabbit polyclonal to CCND3. Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
- ReactivityHuman, Mouse
- Storage Instruction-20°C,2°C to 8°C
- UNSPSC12352203