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CCND3 antibody

Research Use Only
ORB107017
Biorbyt
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetCCND3

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Overview

  • Supplier
    Biorbyt
  • Product Name
    CCND3 antibody
  • Delivery Days Customer
    16
  • Applications
    Western Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Applications Supplier
    WB: 1:1000 IHC-P, WB
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Clone ID
    RB43029
  • Conjugate
    Unconjugated
  • Gene ID896
  • Target name
    CCND3
  • Target description
    cyclin D3
  • Target synonyms
    D3-type cyclin; G1/S-specific cyclin-D3
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP30281
  • Protein Name
    G1/S-specific cyclin-D3
  • Scientific Description
    Rabbit polyclonal to CCND3. Regulatory component of the cyclin D3-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D3/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
  • Reactivity
    Human, Mouse
  • UNSPSC
    12352203