CCR4 antagonist 3

MedChem Express

CCR4 antagonist 3

10

Research Use Only

99.94

C14H12N2S

240.32

CCR4 antagonist 3 is a potent chemokine receptor 4 (CCR4) antagonist with an IC 50 value of 1.7 microM for [ 125 I]TARC (thymus and activation regulated chemokine). CCR4 antagonist 3 inhibits binding of radiolabeled TARC and macrophage-derived chemokine (MDC) to CCR4 receptors on the surface of CEM cells. CCR4 antagonist 3 also inhibits the in vitro migration of CEM cells mediated by TARC (IC50 = 6.4 microM) [1] .

CC1=CSC(NC2=C3C=CC=CC3=CC=C2)=N1

-20°C,2°C to 8°C

12352200