CCR5 Polyclonal Antibody

Elabscience

CCR5 Polyclonal Antibody

12

ImmunoHistoChemistry

Research Use Only

Polyclonal

0.55 mg/ml

Unconjugated

Ccr5

C-C motif chemokine receptor 5

AM4-7, CD195, Cmkbr5, C-C chemokine receptor type 5, C-C CKR-5, CC-CKR-5, CCR-5, MIP-1 alpha receptor, chemokine (C-C motif) receptor 5, chemokine (C-C) receptor 5

Rabbit

IgG

C-C chemokine receptor type 5

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation.

-20°C

41116161