CD11b antibody [ICRF44]
GTX00481
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking, Other Application
Product group Antibodies
ReactivityHuman, Monkey, Porcine, Primate
TargetITGAM
Overview
- SupplierGeneTex
- Product NameCD11b antibody [ICRF44]
- Delivery Days Customer9
- ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, Neutralisation/Blocking, Other Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDICRF44
- Concentration0.5 mg/ml
- ConjugateUnconjugated
- Gene ID3684
- Target nameITGAM
- Target descriptionintegrin subunit alpha M
- Target synonymsantigen CD11b (p170); CD11 antigen-like family member B; CD11B; cell surface glycoprotein MAC-1 subunit alpha; complement component 3 receptor 3 subunit; CR-3 alpha chain; CR3A; integrin alpha-M; integrin, alpha M (complement component 3 receptor 3 subunit); leukocyte adhesion receptor MO1; MAC-1; MAC1A; macrophage antigen alpha polypeptide; macrophage-1 antigen alpha subunit; MO1A; neutrophil adherence receptor alpha-M subunit; SLEB6
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThis gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
- ReactivityHuman, Monkey, Porcine, Primate
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Dyslipidemic Diet-Induced Monocyte Priming and Dysfunction in Non-Human Primates Is Triggered by Elevated Plasma Cholesterol and Accompanied by Altered Histone Acetylation. Short JD et al., 2017, Front ImmunolRead more
- Vitamin D machinery and metabolism in porcine adipose-derived mesenchymal stem cells. Valle YL et al., 2016 Aug 17, Stem Cell Res TherRead more
- Affinity maturation of a novel antagonistic human monoclonal antibody with a long VH CDR3 targeting the Class A GPCR formyl-peptide receptor 1. Douthwaite JA et al., 2015, MAbsRead more
- Glioma grade is associated with the accumulation and activity of cells bearing M2 monocyte markers. Prosniak M et al., 2013 Jul 15, Clin Cancer ResRead more
- Endogenous PMN sialidase activity exposes activation epitope on CD11b/CD18 which enhances its binding interaction with ICAM-1. Feng C et al., 2011 Aug, J Leukoc BiolRead more
- Complement receptor Mac-1 is an adaptor for NB1 (CD177)-mediated PR3-ANCA neutrophil activation. Jerke U et al., 2011 Mar 4, J Biol ChemRead more
- Attenuation of innate immunity by cytomegalovirus IL-10 establishes a long-term deficit of adaptive antiviral immunity. Chang WL et al., 2010 Dec 28, Proc Natl Acad Sci U S ARead more
- Tolerogenic dendritic cells actively inhibit T cells through heme oxygenase-1 in rodents and in nonhuman primates. Moreau A et al., 2009 Sep, FASEB JRead more
- Integrins are not involved in the process of human sperm-oolemmal fusion. Sengoku K et al., 2004 Mar, Hum ReprodRead more
- Interaction of proteinase 3 with CD11b/CD18 (beta2 integrin) on the cell membrane of human neutrophils. David A et al., 2003 Oct, J Leukoc BiolRead more