![CD137, Mouse(LOB12), CF640R conjugate, 0.1mg/mL [26628-22-8] CD137, Mouse(LOB12), CF640R conjugate, 0.1mg/mL [26628-22-8]](https://biotium.com/wp-content/uploads/2016/12/placeholder.png)
CD137, Mouse(LOB12), CF640R conjugate, 0.1mg/mL [26628-22-8]
BNC402012
ApplicationsFunctional Assay, ELISA
Product group Antibodies
ReactivityBovine, Mouse, Rat
TargetTnfrsf9
Overview
- SupplierBiotium
- Product NameCD137, Mouse(LOB12), CF640R conjugate, 0.1mg/mL
- Delivery Days Customer9
- ApplicationsFunctional Assay, ELISA
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDLOB12
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID21942
- Target nameTnfrsf9
- Target descriptiontumor necrosis factor receptor superfamily, member 9
- Target synonyms4-1BB; 4-1BB ligand receptor; A930040I11Rik; AA408498; AI325004; Cd137; CD137 antigen; CDw137; ILA; Ly6; Ly63; secreted CD137 antigen; T-cell antigen 4-1BB; tumor necrosis factor receptor superfamily member 9
- HostRat
- IsotypeIgG2a
- Protein IDP20334
- Protein NameTumor necrosis factor receptor superfamily member 9
- Scientific DescriptionCD137 (4-1BB), a member of the tumor necrosis factor receptor superfamily, is a type I transmembrane glycoprotein expressed on the cell surface of activated splenic T cells and thymocytes. The functions of CD137 in T lymphocytes include regulating activation, proliferation and apoptosis. CD137 and CD28 are costimulatory molecules of T cell activation. Costimulatory molecules are important in initiating anti-tumor immune responses. CD137 plays an important role in regulating T-cell-dependent immune responses. Expression of CD137 correlates negatively with lymphocyte proliferation and positively with the degree of activation-induced cell death caused by mitogen overstimulation. In monocytes, CD137 induces activation, promotes adherence and prolongs survival. The LOB12. 3 antibody is an agonistic antibody that has been shown to stimulate 4-1BB signaling and delay tumor growthin vivo when administered in combination with immune checkpoint inhibitors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Mouse, Rat
- Storage Instruction2°C to 8°C
- UNSPSC12352203