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CD177 antibody [MEM-166]

Name: CD177 antibody [MEM-166]
SKU: GTX75711_G10
Availability: BackOrder

GTX75711

ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot

Product group Antibodies

ReactivityHuman, Primate

TargetCD177

Overview

Supplier
GeneTex
Product Name
CD177 antibody [MEM-166]
Delivery Days Customer
9
Application Supplier Note
FACS: 1/50-1/100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Flow Cytometry, ImmunoPrecipitation, Western Blot
Certification
Research Use Only
Clonality
Monoclonal
Clone ID
MEM-166
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID57126
Target name
CD177
Target description
CD177 molecule
Target synonyms
HNA-2a, HNA2A, NB1, NB1 GP, PRV-1, PRV1, CD177 antigen, NB1 glycoprotein, cell surface receptor, human neutrophil alloantigen 2a, polycythemia rubra vera protein 1
Host
Mouse
Isotype
IgG1
Protein IDQ8N6Q3
Protein Name
CD177 antigen
Scientific Description
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegeners granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]
Reactivity
Human, Primate
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

Jankowska AM, Szpurka H, Calabro M, et al. Loss of expression of neutrophil proteinase-3: a factor contributing to thrombotic risk in paroxysmal nocturnal hemoglobinuria. Haematologica. 2011,96(7):954-62. doi: 10.3324/haematol.2010.029298
Read this paper