CD177 antibody [MEM-166]
GTX75711
ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot
Product group Antibodies
ReactivityHuman, Primate
TargetCD177
Overview
- SupplierGeneTex
- Product NameCD177 antibody [MEM-166]
- Delivery Days Customer9
- Antibody SpecificityThis antibody recognizes human CD177 (neutrophil glycoprotein NB1).
- Application Supplier NoteFACS: 1/50-1/100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry, ImmunoPrecipitation, Western Blot
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDMEM-166
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID57126
- Target nameCD177
- Target descriptionCD177 molecule
- Target synonymsCD177 antigen; cell surface receptor; HNA2A; HNA-2a; human neutrophil alloantigen 2a; NB1; NB1 glycoprotein; NB1 GP; polycythemia rubra vera protein 1; PRV1; PRV-1
- HostMouse
- IsotypeIgG1
- Protein IDQ8N6Q3
- Protein NameCD177 antigen
- Scientific DescriptionThis gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegeners granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]
- ReactivityHuman, Primate
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Loss of expression of neutrophil proteinase-3: a factor contributing to thrombotic risk in paroxysmal nocturnal hemoglobinuria. Jankowska AM et al., 2011 Jul, HaematologicaRead more