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ProductsBack/CD23 (Fc Epsilon RII)(FCER2/3592), CF405S conjugate, 0.1mg/mL [26628-22-8]
CD23 (Fc Epsilon RII)(FCER2/3592), CF405S conjugate, 0.1mg/mL [26628-22-8]

CD23 (Fc Epsilon RII)(FCER2/3592), CF405S conjugate, 0.1mg/mL [26628-22-8]

BNC043592
Biotium
ApplicationsImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetFCER2
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Overview

  • Supplier
    Biotium
  • Product Name
    CD23 (Fc Epsilon RII)(FCER2/3592), CF405S conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    FCER2/3592
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID2208
  • Target name
    FCER2
  • Target description
    Fc fragment of IgE receptor II
  • Target synonyms
    BLAST-2; CD23; CD23 antigen; CD23A; CLEC4J; C-type lectin domain family 4, member J; Fc epsilon receptor II; Fc fragment of IgE, low affinity II, receptor for (CD23); FCE2; fc-epsilon-RII; IGEBF; immunoglobulin E-binding factor; immunoglobulin epsilon-chain; low affinity immunoglobulin epsilon Fc receptor; lymphocyte IgE receptor
  • Host
    Mouse
  • Isotype
    IgG2b
  • Protein IDP06734
  • Protein Name
    Low affinity immunoglobulin epsilon Fc receptor
  • Scientific Description
    CD23 (FCE2) is a type II integral membrane glycoprotein that is expressed on mature B cells, monocytes, eosinophils, platelets and dendritic cells. CD23 is a low affinity IgE receptor that mediates IgE-dependent cytotoxicity and phagocytosis by macrophages and eosinophils. CD23 associates as an oligomer where cooperative binding of at least two lectin domains is required for high affinity IgE binding to CD23. It may play a role in antigen presentation by B cells by interacting with CD40. CD23 has been shown to be associated with the Fyn tyrosine kinase. The truncated molecule can be secreted, then function as a potent mitogenic growth factor. CD23 is expressed on a subpopulation of peripheral blood cells, B-lymphocytes and on EBV transformed B lymphoblastoid cell lines. CD23 is also detected in neoplastic cells from cases of B cell chronic lymphocytic leukemia and some cases on centroblastic/centrocytic lymphoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Human
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203