
Western Blot Positive WB detected in THP-1 whole cell lysate All lanes CD31 antibody at 0.95microg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 125 KDa Observed band size: 125 KDa
CD31 Recombinant Monoclonal Antibody
CSB-RA017767A0HU
ApplicationsFlow Cytometry, Western Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetPECAM1
Overview
- SupplierCusabio
- Product NameCD31 Recombinant Monoclonal Antibody
- Delivery Days Customer20
- ApplicationsFlow Cytometry, Western Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID7B7
- ConjugateUnconjugated
- Gene ID5175
- Target namePECAM1
- Target descriptionplatelet and endothelial cell adhesion molecule 1
- Target synonymsCD31; CD31 antigen; CD31/EndoCAM; endoCAM; GPIIA'; PECA1; PECAM-1; platelet endothelial cell adhesion molecule; platelet endothelial cell adhesion molecule-1
- IsotypeIgG
- Protein IDP16284
- Protein NamePlatelet endothelial cell adhesion molecule
- Scientific DescriptionInduces susceptibility to atherosclerosis (By similarity). Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Prevents phagocyte ingestion of closely apposed viable cells by transmitting detachment signals, and changes function on apoptosis, promoting tethering of dying cells to phagocytes (the encounter of a viable cell with a phagocyte via the homophilic interaction of PECAM1 on both cell surfaces leads to the viable cells active repulsion from the phagocyte. During apoptosis, the inside-out signaling of PECAM1 is somehow disabled so that the apoptotic cell does not actively reject the phagocyte anymore. The lack of this repulsion signal together with the interaction of the eat-me signals and their respective receptors causes the attachment of the apoptotic cell to the phagocyte, thus triggering the process of engulfment). Isoform Delta15 is unable to protect against apoptosis. Modulates BDKRB2 activation. Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in human umbilical cord vein cells (HUVEC).
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203