CD33 Antibody (clone WM53, Azide-free, BSA-free)

LifeSpan BioSciences

CD33 Antibody (clone WM53, Azide-free, BSA-free)

23

Human CD33

The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. This antibody recognizes a 67kDa glycoprotein, which is identified as CD33 (HLDA IV. WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies. these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells. ELISA: Order BSA-free antibody format for coating.. Flo (0.5 - 1 µg/10E6 cells), Func, IF (0.5 - 1 µg/ml) The applications listed have been tested for the unmodified form of this product. Other forms have not been tested. This antibody recognizes a 67kDa glycoprotein, which is identified as CD33 (HLDA IV. WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies. these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells. ELISA: Order BSA-free antibody format for coating.

Functional Assay, Flow Cytometry, ImmunoFluorescence

Research Use Only

Monoclonal

WM53

1 mg/ml

Unconjugated

...

CD33

CD33 molecule

CD33 antigen (gp67); CD33 molecule transcript; gp67; myeloid cell surface antigen CD33; p67; sialic acid-binding Ig-like lectin 3; SIGLEC3; SIGLEC-3

Mouse

IgG1

Human

2°C to 8°C

12352203