CD33 Antibody

Biorbyt

CD33 Antibody

10

The concentration stated for each application is a general starting point. Variations in protocols, secondaries and substrates may require the CD33 antibody to be titered up or down for optimal performance.1. Not suitable for use in FFPE IHC testing.

Flow Cytometry

Flow cytometry: 1-2ug/million cells FACS

Research Use Only

Monoclonal

WM53

Unconjugated

CD33

CD33 molecule

CD33 antigen (gp67); CD33 molecule transcript; gp67; myeloid cell surface antigen CD33; p67; sialic acid-binding Ig-like lectin 3; SIGLEC3; SIGLEC-3

Mouse

IgG1

This antibody recognizes a 67kDa glycoprotein, which is identified as CD33 (HLDA IV; WS Code M-505). CD33 is a transmembrane protein of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. It belongs to the immunoreceptor tyrosine-based inhibitory motif (ITIM)-containing molecules able of recruiting protein tyrosine phosphatases SHP-1 and SHP-2 to signal assemblies; these ITIMs are also used for ubiquitin-mediated removal of the receptor from the cell surface. CD33 is expressed on cells of myelomonocytic lineage, binds sialic acid residues in N- and O-glycans on cell surfaces, and is a therapeutic target for acute myeloid leukemia. CD33 is expressed on myeloid progenitors, monocytes, granulocytes, dendritic cells and mast cells. It is absent on platelets, lymphocytes, erythrocytes and hematopoietic stem cells.

Human

-20°C,2°C to 8°C

12352203