CD4 Antibody

Biorbyt

CD4 Antibody

16

Optimal dilution of the antibody should be determined by the researcher.

ELISA (order BSA-free format for coating & Azide),Neutralization Studies (order BSA/azide-free format),Flow cytometry: 1-2ug/million cells in 0.1ml,Immunofluorescence: 1-2ug/ml ELISA, FACS, IF, NeA

Research Use Only

Monoclonal

GK1.5

Unconjugated

Cd4

CD4 antigen

L3T; L3T4; Ly-; Ly-4; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4

Rat

IgG2b

T-cell surface glycoprotein CD4

CD4 is a member of the Ig superfamily, primarily expressed on most thymocytes, a subset of T cells, and weakly on macrophages and dendritic cells. It acts as a coreceptor with the TCR during T cell activation and thymic differentiation by binding MHC class II and associating with the protein tyrosine kinase, lck. CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally.This antibody blocks helper T cell responses to MHC class II antigens, including cytolysis, proliferation, allogeneic B cell help, and release of lymphokines.

Mouse

-20°C,2°C to 8°C

12352203