CD4 mAb (GK 1.5), InVivoPure+
AK3602P+
ApplicationsOther Application
Product group Antibodies
ReactivityMouse
TargetCd4
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Overview
- SupplierInVivo Biotech
- Product NameCD4 mAb (GK 1.5), InVivoPure+
- Delivery Days Customer5
- ApplicationsOther Application
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDGK 1.5
- Concentration1 mg/ml
- ConjugateUnconjugated
- Estimated Purity>=95%
- FormulationLiquid
- Gene ID12504
- Target nameCd4
- Target descriptionCD4 antigen
- Target synonymsL3T; L3T4; Ly-; Ly-4; T-cell differentiation antigen L3T4; T-cell surface antigen T4/Leu-3; T-cell surface glycoprotein CD4
- HostMouse
- IsotypeIgG2b
- Protein IDP06332
- Protein NameT-cell surface glycoprotein CD4
- Scientific DescriptionThe monoclonal antibody GK1.5 reacts with the mouse CD4 molecule, a 55 kDa cell surface receptor expressed by the majority of thymocytes, a subpopulation of mature T cells and dendritic cells. CD4 binds to MHC class II on the surface of antigen-presenting cells and plays an important role both in the development of T cells and in the optimal function of mature T cells. In T cells, CD4 associates with the protein tyrosine kinase p56lck via its cytoplasmic tail. The binding of GK1.5 is blocked by the antibody RM4-5, which competes with GK1.5 for the same binding site on the CD4 molecule. GK1.5 significantly increased the proportion of peripheral CD4+CD25+Foxp3+ Treg cells in CD4+ T cells in mice without altering their immunosuppressive function. The antibody profoundly blocks antigen-specific reactive mouse helper T lymphocyte lines of class II MHC.
- ReactivityMouse
- UNSPSC12352203