FACS analysis of human peripheral blood lymphocytes using GTX00526-11 CD45 antibody [HI30] (PerCP-Cy5.5). Solid line : Primary antibody Dashed line : PerCP-Cy5.5 mouse IgG1 isotype control Antibody amount : 0.25 microg
FACS analysis of human peripheral blood lymphocytes using GTX00526-11 CD45 antibody [HI30] (PerCP-Cy5.5). Solid line : Primary antibody Dashed line : PerCP-Cy5.5 mouse IgG1 isotype control Antibody amount : 0.25 microg
CD45 antibody [HI30] (PerCP-Cy5.5)
GTX00526-11
ApplicationsFlow Cytometry
Product group Antibodies
ReactivityHuman, Primate
TargetPTPRC
Overview
- SupplierGeneTex
- Product NameCD45 antibody [HI30] (PerCP-Cy5.5)
- Delivery Days Customer9
- Antibody SpecificityThis antibody recognizes all isoforms of human CD45 antigen (Leukocyte Common Antigen).
- Application Supplier NoteFACS: 0.25 microg (5 microl) for 105-108 cells in 100 microl sample per test. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsFlow Cytometry
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDHI30
- Concentration0.05 mg/ml
- ConjugateDouble Conjugated
- FormulationLiquid
- Gene ID5788
- Target namePTPRC
- Target descriptionprotein tyrosine phosphatase receptor type C
- Target synonymsB220; CD45; CD45 antigen; CD45R; GP180; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, c polypeptide; receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen
- HostMouse
- IsotypeIgG1
- Protein IDP08575
- Protein NameReceptor-type tyrosine-protein phosphatase C
- Scientific DescriptionThe protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
- ReactivityHuman, Primate
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Divergent Effects of Acute and Prolonged Interleukin 33 Exposure on Mast Cell IgE-Mediated Functions. Roennberg E et al., 2019, Front ImmunolRead more
- Structural analysis of ischemic stroke thrombi: histological indications for therapy resistance. Staessens S et al., 2020, HaematologicaRead more
- Ex vivo-expanded baboon CD39 + regulatory T cells prevent rejection of porcine islet xenografts in NOD-SCID IL-2rgamma(-/-) mice reconstituted with baboon peripheral blood mononuclear cells. Huang D et al., 2017 Nov, XenotransplantationRead more
- Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice. Strowig T et al., 2011 Aug 9, Proc Natl Acad Sci U S ARead more
- Anti-CD45RO suppresses human immunodeficiency virus type 1 replication in microglia: role of Hck tyrosine kinase and implications for AIDS dementia. Kim MO et al., 2006 Jan, J VirolRead more
- Cell surface sialic acids do not affect primary CD22 interactions with CD45 and surface IgM nor the rate of constitutive CD22 endocytosis. Zhang M et al., 2004 Nov, GlycobiologyRead more
- Inducible CD40 expression mediates NFkappaB activation and cytokine secretion in human colonic fibroblasts. Gelbmann CM et al., 2003 Oct, GutRead more
- CD45 controls interleukin-4-mediated IgE class switch recombination in human B cells through its function as a Janus kinase phosphatase. Yamada T et al., 2002 Aug 9, J Biol ChemRead more
- Differential incorporation of CD45, CD80 (B7-1), CD86 (B7-2), and major histocompatibility complex class I and II molecules into human immunodeficiency virus type 1 virions and microvesicles: implications for viral pathogenesis and immune regulation. Esser MT et al., 2001 Jul, J VirolRead more
- Human bronchial intraepithelial T lymphocytes as a distinct T-cell subset: their long-term survival in SCID-Hu chimeras. Goto E et al., 2000 Apr, Am J Respir Cell Mol BiolRead more