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ProductsBack/CD45 / LCA (B-Cell Marker) (F10-89-4), CF640R conjugate, 0.1mg/mL [26628-22-8]

CD45 / LCA (B-Cell Marker) (F10-89-4), CF640R conjugate, 0.1mg/mL [26628-22-8]

BNC401522
Biotium
ApplicationsImmunoFluorescence, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetPTPRC
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Overview

  • Supplier
    Biotium
  • Product Name
    CD45 / LCA (B-Cell Marker) (F10-89-4), CF640R conjugate, 0.1mg/mL
  • Delivery Days Customer
    9
  • Applications
    ImmunoFluorescence, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    F10-89-4
  • Concentration
    0.1 mg/ml
  • Conjugate
    Other Conjugate
  • Gene ID5788
  • Target name
    PTPRC
  • Target description
    protein tyrosine phosphatase receptor type C
  • Target synonyms
    B220; CD45; CD45 antigen; CD45R; GP180; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, c polypeptide; receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen
  • Host
    Mouse
  • Isotype
    IgG2a
  • Protein IDP08575
  • Protein Name
    Receptor-type tyrosine-protein phosphatase C
  • Scientific Description
    CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. Multiple isoforms of CD45R are distributed throughout the immune system according to cell type. These isoforms arise because of alternative splicing of exons 4, 5, and 6. The corresponding protein domains are characterized by the binding of monoclonal antibodies specific for CD45RA (exon 4), CD45RB (exon 5), CD45RC (exon 6) and CD45RO (exons 4 to 6 spliced out). The variation in these isoforms is localized to the extracellular domain of CD45R, while the intracellular domain is conserved. CD45R functions as a phosphor-tyrosine phosphatase. This MAb reacts with all isoforms of CD45R expressed by all hematopoietic cells, except erythrocytes, having a higher level of expression on lymphocytes than on granulocytes (Workshop IV). Antibody to CD45 is useful in differential diagnosis of lymphoid tumors from non-hematopoietic undifferentiated neoplasms.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
  • Source
    Animal
  • Reactivity
    Bovine, Human, Mouse
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203