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ProductsBack/CD45RO antibody [UCHL1]

CD45RO antibody [UCHL1]

Research Use Only
GTX00596
GeneTex
ApplicationsFlow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking
DownloadDatasheet
Product group Antibodies
ReactivityHuman, Primate
TargetPTPRC
Price on request
Packing Size
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Overview

  • Supplier
    GeneTex
  • Product Name
    CD45RO antibody [UCHL1]
  • Delivery Days Customer
    9
  • Applications
    Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin, Neutralisation/Blocking
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    UCHL1
  • Concentration
    0.5 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5788
  • Target name
    PTPRC
  • Target description
    protein tyrosine phosphatase receptor type C
  • Target synonyms
    B220; CD45; CD45 antigen; CD45R; GP180; LCA; L-CA; LY5; protein tyrosine phosphatase, receptor type, c polypeptide; receptor-type tyrosine-protein phosphatase C; T200; T200 glycoprotein; T200 leukocyte common antigen
  • Host
    Mouse
  • Isotype
    IgG2a
  • Scientific Description
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012]
  • Reactivity
    Human, Primate
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12352203

References

  • Establishment and Characterization of Human Germline Stem Cell Line with Unlimited Proliferation Potentials and no Tumor Formation. Hou J et al., 2015 Nov 20, Sci Rep
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  • Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Zhao E et al., 2016 Jan, Nat Immunol
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  • A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates. Kap YS et al., 2009 Dec, J Histochem Cytochem
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  • The lack of epithelial interleukin-7 and BAFF/BLyS gene expression in prostate cancer as a possible mechanism of tumor escape from immunosurveillance. Di Carlo E et al., 2009 May 1, Clin Cancer Res
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  • Increased T-bet+ cytotoxic effectors and type I interferon-mediated processes in chronic graft-versus-host disease of the oral mucosa. Imanguli MM et al., 2009 Apr 9, Blood
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  • Anti-CD45RO suppresses human immunodeficiency virus type 1 replication in microglia: role of Hck tyrosine kinase and implications for AIDS dementia. Kim MO et al., 2006 Jan, J Virol
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  • Lupus IgG VH4.34 antibodies bind to a 220-kDa glycoform of CD45/B220 on the surface of human B lymphocytes. Cappione AJ et al., 2004 Apr 1, J Immunol
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  • The transmembrane protein-tyrosine phosphatase CD45 is associated with decreased insulin receptor signaling. Kulas DT et al., 1996 Jan 12, J Biol Chem
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