CD8 alpha antibody [Hit8a]
GTX01486
ApplicationsFlow Cytometry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
Product group Antibodies
ReactivityHuman, Primate
TargetCD8A
Overview
- SupplierGeneTex
- Product NameCD8 alpha antibody [Hit8a]
- Delivery Days Customer9
- ApplicationsFlow Cytometry, ImmunoHistoChemistry, ImmunoHistoChemistry Frozen
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDHit8a
- Concentration0.5 mg/ml
- ConjugateUnconjugated
- Gene ID925
- Target nameCD8A
- Target descriptionCD8a molecule
- Target synonymsCD8; CD8 antigen, alpha polypeptide (p32); Leu2; Leu2 T-lymphocyte antigen; OKT8 T-cell antigen; p32; T cell co-receptor; T8 T-cell antigen; T-cell antigen Leu2; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2
- HostMouse
- IsotypeIgG1
- Scientific DescriptionThe CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
- ReactivityHuman, Primate
- Storage Instruction2°C to 8°C
- UNSPSC12352203
References
- Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. Coppieters KT et al., 2012 Jan 16, J Exp MedRead more
- Low BCR-ABL expression levels in hematopoietic precursor cells enable persistence of chronic myeloid leukemia under imatinib. Kumari A et al., 2012 Jan 12, BloodRead more
- Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments. Kryczek I et al., 2009 Aug 6, BloodRead more