![CD8A (Cytotoxic- & Suppressor T-Cell Marker)(UCHT4), CF640R conjugate, 0.1mg/mL [26628-22-8] CD8A (Cytotoxic- & Suppressor T-Cell Marker)(UCHT4), CF640R conjugate, 0.1mg/mL [26628-22-8]](https://biotium.com/wp-content/uploads/2021/02/view_image-166.jpeg)
CD8A (Cytotoxic- & Suppressor T-Cell Marker)(UCHT4), CF640R conjugate, 0.1mg/mL [26628-22-8]
BNC401628
ApplicationsFunctional Assay, Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation
Product group Antibodies
ReactivityBovine, Human, Mouse
TargetCD8A
Overview
- SupplierBiotium
- Product NameCD8A (Cytotoxic- & Suppressor T-Cell Marker)(UCHT4), CF640R conjugate, 0.1mg/mL
- Delivery Days Customer9
- ApplicationsFunctional Assay, Flow Cytometry, ImmunoFluorescence, ImmunoPrecipitation
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone IDUCHT4
- Concentration0.1 mg/ml
- ConjugateOther Conjugate
- Gene ID925
- Target nameCD8A
- Target descriptionCD8a molecule
- Target synonymsCD8; CD8 antigen, alpha polypeptide (p32); Leu2; Leu2 T-lymphocyte antigen; OKT8 T-cell antigen; p32; T cell co-receptor; T8 T-cell antigen; T-cell antigen Leu2; T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2
- HostMouse
- IsotypeIgG2a
- Protein IDP01732
- Protein NameT-cell surface glycoprotein CD8 alpha chain
- Scientific DescriptionCD8 is a cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class 1 and through its association with protein tyrosine kinase p56lck plays a role in T cell development and activation of mature T cells. For mature T-cells, CD4 and CD8 are mutually exclusive, so anti-CD8, generally used in conjunction with anti-CD4. It is a useful marker for distinguishing helper/inducer T-lymphocytes, and most peripheral T-cell lymphomas are CD4 /CD8-. Anaplastic large cell lymphoma is usually CD4 and CD8-, and in T-lymphoblastic lymphoma/leukemia, CD4 and CD8 are often co-expressed. CD8 is also found in littoral cell angioma of the spleen. This MAb binds to the CD8 alpha chain, at an epitope distinct from that recognized by UCHT14. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
- SourceAnimal
- ReactivityBovine, Human, Mouse
- Storage Instruction2°C to 8°C
- UNSPSC12352203