
IHC-P analysis of human breast carcinoma tissue using GTX50195 CDC2 (phospho Thr161) antibody. Left : Primary antibody Right : Primary antibody pre-incubated with the antigen specific peptide
CDC2 (phospho Thr161) antibody

GTX50195
ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman
TargetCDK1
Overview
- SupplierGeneTex
- Product NameCDC2 (phospho Thr161) antibody - Orthogonal Validated
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:1000. IHC-P: 1:50-1:100. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration1 mg/ml
- ConjugateUnconjugated
- FormulationLiquid
- Gene ID983
- Target nameCDK1
- Target descriptioncyclin dependent kinase 1
- Target synonymsCDC2; CDC28A; cell cycle controller CDC2; cell division control protein 2 homolog; cell division cycle 2, G1 to S and G2 to M; cell division protein kinase 1; cyclin-dependent kinase 1; p34 protein kinase; P34CDC2
- HostRabbit
- IsotypeIgG
- Modification TypePhosphorylated
- Protein IDP06493
- Protein NameCyclin-dependent kinase 1
- Scientific DescriptionThe protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK. Chang LC et al., 2014 Sep, Br J PharmacolRead more