CDH12 Polyclonal Antibody

Reddot Biotech

CDH12 Polyclonal Antibody

5

1.74 mg/ml

CDH12

cadherin 12

brain-cadherin; Br-cadherin; cadherin, neural type, 2; cadherin-12; CDHB; N-cadherin 2; neural type cadherin 2; neuronal cadherin 2

This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis.

-20°C

12352203