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ProductsBack/CDK4 Recombinant Monoclonal Antibody
Western Blot Positive WB detected in: Jurkat whole cell lysate, Hela whole cell lysate, 293 whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate, K562 whole cell lysate, A549 whole cell lysate All lanes: CDK4 antibody at 1:1500 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 34, 21 kDa Observed band size: 34 kDa
Western Blot Positive WB detected in: Jurkat whole cell lysate, Hela whole cell lysate, 293 whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate, K562 whole cell lysate, A549 whole cell lysate All lanes: CDK4 antibody at 1:1500 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 34, 21 kDa Observed band size: 34 kDa
Western Blot Positive WB detected in: Jurkat whole cell lysate, Hela whole cell lysate, 293 whole cell lysate, MCF-7 whole cell lysate, HepG2 whole cell lysate, K562 whole cell lysate, A549 whole cell lysate All lanes: CDK4 antibody at 1:1500 Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 34, 21 kDa Observed band size: 34 kDa

CDK4 Recombinant Monoclonal Antibody

CSB-RA697694A0HU
Cusabio
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetCDK4
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Overview

  • Supplier
    Cusabio
  • Product Name
    CDK4 Recombinant Monoclonal Antibody
  • Delivery Days Customer
    20
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Monoclonal
  • Clone ID
    8H4
  • Conjugate
    Unconjugated
  • Gene ID1019
  • Target name
    CDK4
  • Target description
    cyclin dependent kinase 4
  • Target synonyms
    cell division protein kinase 4; CMM3; cyclin-dependent kinase 4; PSK-J3
  • Isotype
    IgG
  • Protein IDP11802
  • Protein Name
    Cyclin-dependent kinase 4
  • Scientific Description
    Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex.
  • Reactivity
    Human
  • Storage Instruction
    -20°C or -80°C
  • UNSPSC
    12352203