CDK5R1 Polyclonal Antibody
RD266296A
ApplicationsImmunoFluorescence
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetCDK5R1
Overview
- SupplierReddot Biotech
- Product NameCDK5R1 Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsImmunoFluorescence
- CertificationResearch Use Only
- Concentration1 mg/ml
- ConjugateUnconjugated
- Gene ID8851
- Target nameCDK5R1
- Target descriptioncyclin dependent kinase 5 regulatory subunit 1
- Target synonymsCDK5 activator 1; CDK5P35; CDK5R; cyclin-dependent kinase 5 activator 1; NCK5A; neuronal CDK5 activator; p23; p25; p35; p35nck5a; regulatory partner for CDK5 kinase; tau protein kinase II 23kDa subunit; TPKII regulatory subunit
- HostRabbit
- IsotypeIgG
- Scientific DescriptionThe protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimers disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimers disease.
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203