CDK9/10/GSK3beta-IN-1 [2423045-06-9]
HY-151375
Overview
- SupplierMedChem Express
- Product NameCDK9/10/GSK3beta-IN-1 [2423045-06-9]
- Delivery Days Customer10
- CAS Number2423045-06-9
- CertificationResearch Use Only
- Molecular FormulaC29H24ClN3O4S
- Molecular Weight546.04
- Scientific DescriptionCDK9/10/GSK3beta-IN-1 (compound 13c) is a kinase inhibitor (Flavopiridol (HY-10005) analogue) that effectively inhibits HsGSK3beta (IC50=59 nM), HsCDK9/CyclinT (IC50=64 nM), HsCDK5/p25 (IC50=1.093 microM) and HsCDK2/CyclinA (IC50=1.725 microM). CDK9/10/GSK3beta-IN-1 has anti-cancer cellular activity comparable to or higher than that of Flavopiridol. CDK9/10/GSK3beta-IN-1 shows high anti-proliferative activity in vitro against up to seven cancer cell lines[1].
- SMILESClC1=CC(SC2=NC3=CC=CC=C3N2C)=CC=C1C(OC4=C5C(O)=CC(O)=C4C(CC6)=CCN6C)=CC5=O
- UNSPSC12131703