Immunohistochemistry of paraffin-embedded Human brain tissue using p16 Polyclonal Antibody at dilution 1:60
Immunohistochemistry of paraffin-embedded Human brain tissue using p16 Polyclonal Antibody at dilution 1:60
CDKN2A Polyclonal Antibody
E-AB-13142
Product group Antibodies
Overview
- SupplierElabscience
- Product NameCDKN2A Polyclonal Antibody
- Delivery Days Customer12
- Applications SupplierELISA IHC
- CertificationResearch Use Only
- Concentration1mg/ml
- Scientific DescriptionThis gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.
- UNSPSC12352203