Bio-Connect

CDKN2AIP Polyclonal Antibody

RD75301A
Reddot Biotech
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman
TargetCDKN2AIP
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    CDKN2AIP Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    ELISA, ImmunoHistoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.3 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID55602
  • Target name
    CDKN2AIP
  • Target description
    CDKN2A interacting protein
  • Target synonyms
    CARF; CDKN2A-interacting protein; collaborates/cooperates with ARF (alternate reading frame) protein; collaborator of ARF
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus.
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203