CDKN2AIP Polyclonal Antibody

Reddot Biotech

CDKN2AIP Polyclonal Antibody

5

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

0.3 mg/ml

Unconjugated

CDKN2AIP

CDKN2A interacting protein

CARF; CDKN2A-interacting protein; collaborates/cooperates with ARF (alternate reading frame) protein; collaborator of ARF

Rabbit

IgG

CDKN2AIP (CDKN2A-interacting protein), also known as CARF, is a 580 amino acid protein that activates p53 via p14 ARF (alternate reading frame)-dependent and independent pathways. CDKN2AIP-dependent activation of p53, a protein that up-regulates growth arrest and apoptosis-related genes in response to stress signals, leads to an enhancement of p53 function. Expression levels of CDKN2AIP and p53 show an inverse relationship that is caused by a negative-feedback control via a proteasome-mediated degradation pathway. CDKN2AIP is expressed ubiquitously across tissue samples and, along with p14 ARF, is localized to the perinucleolar region within the nucleus.

Human

-20°C

12352203