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Celastramycin A

Research Use Only
HY-122292
MedChem Express
CAS Number188988-62-7
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Product group Chemicals
Molecular Weight390.69
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Celastramycin A [188988-62-7]
  • Delivery Days Customer
    5
  • CAS Number
    188988-62-7
  • Certification
    Research Use Only
  • Molecular Formula
    C17H18Cl3NO3
  • Molecular Weight
    390.69
  • Scientific Description
    Celastramycin A is an antibiotic isolated from Streptomyces MaB-QuH-8, which exhibits antimicrobial activity against series of gram-negative bacteria and mycobacteria, with MICs between 0.05-3.1 microg/ml[1]. Celastramycin A exhibits immunosuppressing efficacy in ex vivo Drosophila through immune deficiency pathway (IC50 of 0.008 microg/ml), inhibits the immunoresponse in human innate immunity through TNF-alpha signaling, inhibits IL-8 production in HUEVCs with IC50 of 0.06 microg/ml[2].
  • SMILES
    O=C(C1=C(O)C(CCCCCC)=CC(Cl)=C1O)C2=CC(Cl)=C(Cl)N2
  • UNSPSC
    12352200