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Celastramycin A (isomer)

Research Use Only
HY-N12905
MedChem Express
CAS Number491600-94-3
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Product group Chemicals
Molecular Weight390.69
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Celastramycin A (isomer) [491600-94-3]
  • Delivery Days Customer
    5
  • CAS Number
    491600-94-3
  • Certification
    Research Use Only
  • Molecular Formula
    C17H18Cl3NO3
  • Molecular Weight
    390.69
  • Scientific Description
    Celastramycin A isomer is an isomer of Celastramycin A (HY-122292), an antibiotic against Gram-negative bacteria and Mycobacterium tuberculosis with an MIC of 0.05-3.1 microg/mL. Celastramycin A exerts immunosuppressive effects in Drosophila ex vivo via the immunodeficiency pathway (IC50 of 8 ng/mL), inhibits human innate immune responses via the TNF-alpha pathway, and inhibits IL-8 production in HUEVC with an IC50 of 60 ng/mL[1][2].
  • SMILES
    O=C(C1=C(O)C(CCCCCC)=CC(Cl)=C1O)C2=CNC(Cl)=C2Cl
  • UNSPSC
    12352200