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ProductsBack/Celastrol [34157-83-0]
Chemical Structure
Chemical Structure
Chemical Structure

Celastrol [34157-83-0]

Research Use Only
AG-CN2-0460
AdipoGen Life Sciences
CAS Number34157-83-0
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight450.6
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Celastrol [34157-83-0]
  • Delivery Days Customer
    10
  • ADR Class
    6.1
  • CAS Number
    34157-83-0
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Danger,Excepted quantity
  • Molecular Formula
    C29H38O4
  • Molecular Weight
    450.6
  • Scientific Description
    Anti-obesity agent. Potent leptin sensitizer. Antioxidant. Potent lipid peroxidation inhibitor. NADPH oxidases (NOX1, 2, 4 and 5) inhibitor. Anti-inflammatory. NF-kappaB inhibitor. HSP90 inhibitor and HSP70 inducer. Anticancer agent. Apoptosis and autophagy inducer. Inhibits PI3K/Akt signaling pathways. Anti-metastatic and anti-angiogenic compound. Reduces VEGFR expression and inhibits HIF-1alpha pathway. Topoisomerase II inhibitor. 20S proteasome chymotrypsin-like activity inhibitor. Potential antiviral and anti-Alzheimers agent. - Chemical. CAS: 34157-83-0. Formula: C29H38O4. MW: 450.6. Isolated from Tripterygium wilfordii. Anti-obesity agent. Potent leptin sensitizer. Antioxidant. Potent lipid peroxidation inhibitor. NADPH oxidases (NOX1, 2, 4 and 5) inhibitor. Anti-inflammatory. NF-kappaB inhibitor. HSP90 inhibitor and HSP70 inducer. Anticancer agent. Apoptosis and autophagy inducer. Inhibits PI3K/Akt signaling pathways. Anti-metastatic and anti-angiogenic compound. Reduces VEGFR expression and inhibits HIF-1alpha pathway. Topoisomerase II inhibitor. 20S proteasome chymotrypsin-like activity inhibitor. Potential antiviral and anti-Alzheimers agent.
  • SMILES
    [H][C@@]12C[C@@](C)(CC[C@]1(C)CC[C@]1(C)C3=CC=C4C(C)=C(O)C(=O)C=C4[C@]3(C)CC[C@@]21C)C(O)=O
  • Storage Instruction
    -20°C,2°C to 8°C
  • UN Number
    UN 2811
  • UNSPSC
    12352200

References

  • The triterpene celastrol as a very potent inhibitor of lipid peroxidation in mitochondria: H. Sassa, et al.; BBRC 172, 890 (1990)
  • Celastrol, a potent antioxidant and anti-inflammatory drug, as a possible treatment for Alzheimer's disease: A.C. Allison, et al.; Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341 (2001)
  • Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production: H.Z. Jin, et al.; J. Nat. Prod. 65, 89 (2002)
  • Apoptosis induction in HL-60 cells and inhibition of topoisomerase II by triterpene celastrol: M. Nagase, et al.; Biosci. Biotechnol. Biochem. 67, 1883 (2003)
  • Inhibition of NF-kappa B activation through targeting I kappa B kinase by celastrol, a quinone methide triterpenoid: J.H. Lee, et al.; Biochem. Pharmacol. 72, 1311 (2006)
  • Celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," is a potent proteasome inhibitor and suppresses human prostate cancer growth in nude mice: H. Yang, et al.; Cancer Res. 66, 4758 (2006)
  • Celastrol, a novel HSP90 inhibitor, depletes Bcr-Abl and induces apoptosis in imatinib-resistant chronic myelogenous leukemia cells harboring T315I mutation: Z. Lu, et al.; Cancer Lett. 290, 182 (2010)
  • Celastrol: Molecular targets of Thunder God Vine: A. Salminen, et al.; BBRC 394, 439 (2010) (Review)
  • Celastrol acts as a potent antimetastatic agent targeting beta1 integrin and inhibiting cell-extracellular matrix adhesion, in part via the p38 mitogen-activated protein kinase pathway: H. Zhu, et al.; J. Pharmacol. Exp. Ther. 334, 489 (2010)
  • Inhibitory action of Celastrol on hypoxia-mediated angiogenesis and metastasis via the HIF-1alpha pathway: L. Huang, et al.; Int. J. Mol. Med. 27, 407 (2011)