PDE10A-HEK293 Cell line | 60410 | BPS Bioscience - Bio-Connect

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Description
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General

Product specifications for - PDE10A-HEK293 Cell line

Overview:
Product group:	Cell Culture
Category:	Cell lines
Application note:	Useful to monitor cAMP and PDE10A signaling pathway activity and to screen activators or inhibitors of PDE10A.
Target:	PDE10A
Target description:	phosphodiesterase 10A

Properties:
Datasheet:	Datasheet
	Research Use Only
UNSPSC:	12352207
Form supplied:	aqueous solution containing DMSO
Storage instructions:	Liquid Nitrogen

Scientific information:
Scientific info:	Recombinant HEK293 cell line expressing human PDE10A2 (phosphodiesterase 10A, accession number NM_006661). N-terminal His-tagged human PDE10A2 has been stably expressed in a human embryonic kidney (HEK293) cell line. PDE10A2 expression was confirmed by Western blotting. The function of PDE10A2 was confirmed by cAMP detection assay. Forskolin is commonly used to raise levels of intracellular cyclic AMP (cAMP). When HEK293 cells are activated by forskolin, cAMP levels are upregulated in parental cells, whereas cells overexpressing PDE10A show reduction in cAMP accumulation. Inhibition of PDE10A activity restores cAMP levels.
Gene ID:	10846
Swiss prot ID:	Q9Y233

Additional information:
Synonyms:	60410; BPS Bioscience; 3,5 cAMP/cGMP phosphodiesterase; ADSD2; cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase 10A; dJ416F21.1 (phosphodiesterase 10A); HSPDE10A; IOLOD; LINC00473; PDE10A19; phosphodiesterase 10A1 (PDE10A1); phosphodiesterase 10A7 (PDE10A7)