Cell Division Cycle 34 homolog(CPTC-CDC34-2), CF405S conjugate, 0.1mg/mL [26628-22-8]

Biotium

Cell Division Cycle 34 homolog(CPTC-CDC34-2), CF405S conjugate, 0.1mg/mL

9

ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

CPTC-CDC34-2

0.1 mg/ml

Other Conjugate

CDC34

cell division cycle 34, ubiqiutin conjugating enzyme

(E3-independent) E2 ubiquitin-conjugating enzyme R1; cell division cycle 34 homolog; E2 ubiquitin-conjugating enzyme R1; E2-CDC34; UBC3; UBCH3; UBE2R1; ubiquitin carrier protein; ubiquitin-conjugating enzyme E2 R1; ubiquitin-conjugating enzyme E2-32 KDA complementing; ubiquitin-conjugating enzyme E2-CDC34; ubiquitin-protein ligase R1

Mouse

IgG1

Ubiquitin-conjugating enzyme E2 R1

Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by the proteolysis of cyclins. The cell division cycle (Cdc) genes are required at various points in the cell cycle. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, which is involved in the initiation of DNA replication. Cdc37 appears to facilitate Cdk4/cyclin D1 complex formation and has been shown to form a stable complex with HSP 90. Cdc34, Cdc27 and Cdc16 function as ubiquitinconjugating enzymes. Cdc34 is thought to be the structural and functional homolog of Saccharomyces cerevisiae Cdc34, which is essential for the G1 to S phase transition. Cdc16 and Cdc27 are components of the APC (anaphase promoting complex) which ubiquitinates cyclin B, resulting in cyclin B/Cdk complex degradation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Animal

Bovine, Human, Mouse

2°C to 8°C

12352203