CEND1 Polyclonal Antibody
RD219691A
ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetCEND1
Overview
- SupplierReddot Biotech
- Product NameCEND1 Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.9 mg/ml
- ConjugateUnconjugated
- Gene ID51286
- Target nameCEND1
- Target descriptioncell cycle exit and neuronal differentiation 1
- Target synonymsBM88; BM88 antigen; cell cycle exit and neuronal differentiation protein 1
- HostRabbit
- IsotypeIgG
- Scientific DescriptionBM88, also known as CEND1 (cell cycle exit and neuronal differentiation protein 1), is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A.
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203