CGAS Polyclonal Antibody

Reddot Biotech

CGAS Polyclonal Antibody

5

Western Blot, ELISA

Research Use Only

Polyclonal

0.78 mg/ml

Unconjugated

CGAS

cyclic GMP-AMP synthase

2'3'-cGAMP synthase; C6orf150; cGAMP synthase; cyclic GMP-AMP synthase; h-cGAS; Mab-21 domain containing 1; mab-21 domain-containing protein 1; MB21D1; protein MB21D1

Rabbit

IgG

Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2,5 phosphodiester linkage at the GpA step and the formation of a 3,5 phosphodiester linkage at the ApG step, producing c[G(2,5)pA(3,5)p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115).

Human

-20°C

12352203