Bio-Connect

CGAS Polyclonal Antibody

RD217843A
Reddot Biotech
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetCGAS
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Overview

  • Supplier
    Reddot Biotech
  • Product Name
    CGAS Polyclonal Antibody
  • Delivery Days Customer
    5
  • Applications
    Western Blot, ELISA
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.78 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID115004
  • Target name
    CGAS
  • Target description
    cyclic GMP-AMP synthase
  • Target synonyms
    2'3'-cGAMP synthase; C6orf150; cGAMP synthase; cyclic GMP-AMP synthase; h-cGAS; Mab-21 domain containing 1; mab-21 domain-containing protein 1; MB21D1; protein MB21D1
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP. Catalysis involves both the formation of a 2,5 phosphodiester linkage at the GpA step and the formation of a 3,5 phosphodiester linkage at the ApG step, producing c[G(2,5)pA(3,5)p]. Has antiviral activity by acting as a key cytosolic DNA sensor, the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses. Binds cytosolic DNA directly, leading to activation and synthesis of cGAMP, a second messenger that binds to and activates TMEM173/STING, thereby triggering type-I interferon production. cGAMP can be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115).
  • Reactivity
    Human
  • Storage Instruction
    -20°C
  • UNSPSC
    12352203