CGS 35601

MedChem Express

CGS 35601

5

Research Use Only

C23H31N3O4S

445.58

CGS 35601 is the inhibitor for endothelin-converting enzyme-1 (ECE-1), neutral endopeptidase 24.11 (NEP), and angiotensin-converting enzyme (ACE), with IC50s of 55, 2, and 22 nM, respectively. CGS 35601 suppresses the big endothelin-1 (big ET-1)- and angiotensin I-induced pressor response, and enhances circulation of atrial natriuretic peptide (ANP), regulates the cardiovascular function in SD rats[1].

CC(C)C[C@H](S)C(NC1(CCCC1)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(O)=O)=O)=O

12352200