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Charybdotoxin

Research Use Only
PCB-4227-s
Biosynth
Product group Proteins / Signaling Molecules
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Overview

  • Supplier
    Biosynth
  • Product Name
    Charybdotoxin
  • Delivery Days Customer
    5
  • Certification
    Research Use Only
  • Scientific Description
    Charybdotoxin (CTX) is a peptide of known structure that inhibits Shaker K+ channels by a pore-blocking mechanism. [95751-30-7] (Scorpion, Leiurus quinquestriatus hebraeus) Pyr-Phe-Thr-Asn-Val-Ser-Cys-Thr-Thr-Ser-Lys-Glu-Cys-Trp-Ser-Val-Cys-Gln-Arg-Leu-His-Asn-Thr-Ser-Arg-Gly-Lys-Cys-Met-Asn-Lys-Lys-Cys-Arg-Cys-Tyr-Ser (Disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35) (M.W. 4295.9) C176H277N57O55S7 Ca2+-Activated K+ Channel Blocker M.L. Garcia, H.-G. Knaus, P. Munujos, R.S. Slaughter, and G.J. Kaczorowski, Am. J. Physiol., 269, C1 (1995). (Review) Gl Gimenez-Gallego, M.A. Navia, J.P. Reben, G.M. Katz, G.J. Kaczorowski, and M.L. Garcia, Proc. Natl. Acad. Sci. USA, 85, 3329 (1988) (Original) P. Lambert, H. Kuroda, N. Chino, T.X. Watanabe, T. Kimura, and S. Sakakibara, Biochem. Biophys. Res. Commun., 170, 684, (1990 (Chem. Synthesis & Pharmacol.) * The biological activity of these peptides is examined by the Division of Pharmacology, Peptide Institute, Inc.
  • Source
    (Scorpion, Leiurus quinquestri
  • UNSPSC
    12352202