CHCHD4 Antibody, FITC conjugated

Cusabio

CHCHD4 Antibody, FITC conjugated

20

Research Use Only

Polyclonal

FITC

CHCHD4

coiled-coil-helix-coiled-coil-helix domain containing 4

coiled-coil-helix-coiled-coil-helix domain-containing protein 4; MIA40; mitochondrial intermembrane space import and assembly protein 40; TIMM40; translocase of inner mitochondrial membrane 40 homolog

Rabbit

IgG

Mitochondrial intermembrane space import and assembly protein 40

Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system.

Human

-20°C or -80°C

12352203