Western blot analysis of extract from HL60 cells using Chk2(Ab-516) Antibody.
Western blot analysis of extract from HL60 cells using Chk2(Ab-516) Antibody.
CHEK2 (Ab-516) Antibody
CSB-PA074742
ApplicationsWestern Blot, ELISA
Product group Antibodies
ReactivityHuman
TargetCHEK2
Overview
- SupplierCusabio
- Product NameCHEK2 (Ab-516) Antibody
- Delivery Days Customer20
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityPolyclonal
- ConjugateUnconjugated
- Gene ID11200
- Target nameCHEK2
- Target descriptioncheckpoint kinase 2
- Target synonymsCDS1; cds1 homolog; checkpoint-like protein CHK2; CHK2; CHK2 checkpoint homolog; hCds1; HuCds1; LFS2; PP1425; RAD53; serine/threonine-protein kinase Chk2
- HostRabbit
- IsotypeIgG
- Protein IDO96017
- Protein NameSerine/threonine-protein kinase Chk2
- Scientific DescriptionThe BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation Melchionna, R. et al. (2000) Nat. Cell Biol. 2, 762-765. Ahn, J.Y. et al. (2000) Cancer Res. 60, 5934-5936. Lee, C.H. and Chung, J.H. (2001) J. Biol. Chem. 276, 30537-30541
- ReactivityHuman
- Storage Instruction-20°C or -80°C
- UNSPSC12352203