AKT inhibitor VIII [612847-09-3]

Catalog number: HY-10355_10mM
Brand: MedChem Express
Packing: 10 mM
Other sizes: Other sizes available
Price: € 185.00
Expected delivery time: 10 days
Quantity:

Product specifications for - AKT inhibitor VIII [612847-09-3]

Overview: 
Product group: Chemicals
Category: Other
CAS No.: 612847-09-3
Properties: 
Purity: >98%
Molecular Formula: C34H29N7O
Molecular weight: 551.64
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Akt Inhibitor VIII is a cell-permeable quinoxaline compound that has been shown to potently, selectively, allosterically, and reversibly inhibit Akt1, Akt2, and Akt3 activity (IC50 = 58 nM, 210 nM, and 2.12 uM, respectively). IC50 value: 58/210/2120 nM(Akt1/2/3) Target: Akt Akt Inhibitor VIII does not exhibit any inhibitory effect against pleckstrin homology (PH) domain-lacking Akts, AGC family kinases, PKA, PKC or SGK. Akt Inhibitor VIII prevails over Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and has been shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 in cultured cells and in mice.
Safety information: 
MSDS: MSDS
Additional information: 
Synonyms: HY-10355
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