Alpelisib [1217486-61-7]

Catalog number: HY-15244_100mg
Brand: MedChem Express
Packing: 100 mg
Other sizes: Also available in other sizes.
Price: € 217.00
Expected delivery time: 10 days

Product specifications for - Alpelisib [1217486-61-7]

Product group: Chemicals
Category: Other
CAS No.: 1217486-61-7
Purity: >98%
Molecular Formula: C19H22F3N5O2S
Molecular weight: 441.47
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: BYL719 is a potent and selective PI3Kalpha inhibitor with IC50 of 5 nM, liitle or no effect on PI3Kbeta/gamma/delta. IC50 value: 5 nM [1] Target: PI3Kalpha in vitro: BYL719 inhibits the proliferation of breast cancer cell lines harboring PIK3CA mutations, correlating with inhibition of various downstream signaling components of the PI3K/Akt pathway [1]. in vivo: BYL719(>270 mg/d) shows statistically significant dose-dependent anti-tumor efficacy in PIK3CA mutant xenograft models in rodents. BYL719 has a low clearance, a half-life of 8.5 h and its exposure increases dose proportionally between 30mg/d and 450mg/d, displaying a low inter-individual variability in Cmax and AUC in human. BYL719(270mg/d) shows first signs of clinical efficacy include 1 confirmed partial response in a patient with ER+ breast cancer, and significant PET responses (PMR) and/or tumor shrinkage are achieved in 8 out of 17 evaluated patients [1].
Safety information: