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Description
Catalog number
CAS No.
Clone ID
News
Vorige
Volgende
Arglabin [84692-91-1]
Catalog number:
AG-CN2-0458-M001
Brand:
AdipoGen Life Sciences
Packing:
1 mg
Other sizes:
Other size available
Price:
€ 80.00
Expected delivery time:
7 days
Quantity:
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General
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Chemical Structure
Chemical Structure...
Chemical Structure
Chemical Structure
Product specifications for - Arglabin [84692-91-1]
Overview:
Product group:
Chemicals
Category:
Other
CAS No.:
84692-91-1
Properties:
Purity:
>98%
Molecular Formula:
C15H18O3
Molecular weight:
246.3
Datasheet:
Datasheet
Research Use Only
UNSPSC:
12352200
Storage instructions:
2-¦C to 8-¦C, -20-¦C
Scientific information:
Scientific info:
Anticancer compound. Farnesyltransferase inhibitor. Potent anti-inflammatory agent. NF-kappaB inhibitor. Inflammasome inhibitor. Antiatherogenic. Prevents the accumulation of lipid containing plaques in arteries. - Chemical. CAS: 84692-91-1. Formula: C15H18O3. MW: 246.3. Semi-synthetic from parthenolide (AG-CN2-0455), which is isolated from Magnolia grandiflora. Anticancer compound. Farnesyltransferase inhibitor. Potent anti-inflammatory agent. NF-kappaB inhibitor. Inflammasome inhibitor. Antiatherogenic. Prevents the accumulation of lipid containing plaques in arteries.
Safety information:
MSDS:
MSDS
Hazard information:
Non-hazardous, Warning
Additional information:
Synonyms:
AG-CN2-0458-M001
In vitro biological activities of arglabin, a sesquiterpene lactone from the Chinese herb Artemisia myriantha Wall: C. Bottex-Gauthier, et al.; Biotechnol. Ther. 4, 77 (1993)
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Arglabin-DMA, a plant derived sesquiterpene, inhibits farnesyltransferase: T.E. Shaikenov, et al.; Oncol. Rep. 8, 173 (2001)
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Biomimetic semisynthesis of arglabin from parthenolide: J.D. Zhai, et al.; JOC 77, 7103 (2012)
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Synthesis and biological evaluation of antitumor-active arglabin derivatives: R. Csuk, et al.; Arch Pharm. 345, 215 (2012)
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Sesquiterpene lactones and their derivatives inhibit high glucose-induced NF-kappaB activation and MCP-1 and TGF-beta1 expression in rat mesangial cells: Q.Q. Jia, et al.; Molecules 18, 13061 (2013)
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Hemisynthesis of a naturally occurring clinically significant antitumor arglabin from ludartin: S.H. Lone & K.A. Bhat; THL 56, 1908 (2015)
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Anti-Inflammatory and antiatherogenic effects of the NLRP3 Inflammasome inhibitor Arglabin in ApoE2.Ki mice fed a high-fat diet: A. Abderrazak, et al.; Circulation 131, 1061 (2015)
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