Vepdegestrant [2229711-68-4]
HY-138642
Overview
- SupplierMedChem Express
- Product NameVepdegestrant [2229711-68-4]
- Delivery Days Customer10
- CAS Number2229711-68-4
- CertificationResearch Use Only
- Estimated Purity98.7%
- Molecular FormulaC45H49N5O4
- Molecular Weight723.9
- Scientific DescriptionVepdegestrant (ARV-471) is an oral estrogen receptor PROTAC protein degrader for breast cancer. Vepdegestrant is a hetero-bifunctional molecule that facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex. Vepdegestrant leads to the ubiquitylation and subsequent degradation of estrogen receptors via the proteasome. Vepdegestrant robustly degrades ER in ER-positive breast cancer cell lines with a half-maximal degradation concentration (DC50) of ~2 nM.
- SMILESO=C([C@@H](N(CC1=C2C=CC(N3CCN(CC4CCN(C5=CC=C([C@H]6[C@@H](C7=CC=CC=C7)CCC8=C6C=CC(O)=C8)C=C5)CC4)CC3)=C1)C2=O)CC9)NC9=O
- Storage Instruction-20°C,-80°C
- UNSPSC12352200