Cetuximab [205923-56-4]

Catalog number: HY-P9905_1mg
Brand: MedChem Express
Packing: 1 mg
Other sizes: Other sizes available
Price: € 300.00
Expected delivery time: 10 days

Product specifications for - Cetuximab [205923-56-4]

Product group: Chemicals
Category: Other
CAS No.: 205923-56-4
Molecular weight: 145543.35
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Cetuximab is a monoclonal antibody that inhibits epidermal growth factor receptor (EGFR), with antitumor activity. In Vitro: Cetuximab (0, 10, 30 and 100 ug/mL) in combination with PBR extract (100, 500 ug/mL) significantly reduces the viability of SW480 colon cancer cells. Cells treated with PBR extract or Cetuximab, are a few PI-stained dead cells. In contrast, the combined treatment of Cetuximab and PBR exhibits relatively fewer cells, and most of them are red-stained dead cells. The combination of PBR extract and Cetuximab induces apoptotic cells, and reduces KRAS and p-p42/44 MAPK levels[1]. In Vivo: Cetuximab (10 mg/kg in PBS, i.p.) with PBR extract suppresses KRAS-mutated colorectal tumor growth in vivo[1]. Cetuximab (1 mg/injection) has effect on the tumour volume but the effect is more pronounced on UT-SCC-14 xenografts. In UT-SCC-14 xenografts, Cetuximab treatment significantly reduces the expression of EGFR, pEGFR and Ki67. The MCT1 and GLUT1 expression is significantly decreased in the Cetuximab-treated groups of both cell lines but differences are more pronounced in UT-SCC-14 xenografts[2].
Safety information: 
Additional information: 
Synonyms: HY-P9905
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Oncogene. 2021 Mar 8. Read more
Nat Commun. 2022 Feb 1;13(1):594. Read more
Mol Cancer. 2021 Jan 18;20(1):17. Read more
J Cell Mol Med. 2020 Jul;24(13):7313-7330. Read more
J Cell Biol. 2021 Nov 1;220(11):e202107103. Read more
Genome Med. 2021 Apr 14;13(1):58. Read more
Cell Res. 2020 Dec;30(12):1063-1077. Read more
Visualizing and Quantifying Drug Distribution in Tissue V. 116240F (2021). Read more
bioRxiv. 2020 Jun. Read more