Laduviglusib trihydrochloride [1782235-14-6]
HY-10182B
CAS Number1782235-14-6
Product group Chemicals
Estimated Purity98.01%
Molecular Weight574.72
Overview
- SupplierMedChem Express
- Product NameLaduviglusib trihydrochloride [1782235-14-6]
- Delivery Days Customer10
- CAS Number1782235-14-6
- Estimated Purity98.01%
- Molecular FormulaC22H21Cl5N8
- Molecular Weight574.72
- Scientific DescriptionLaduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3alpha/beta inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/beta-catenin signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces autophagy.
- SMILESN#CC1=CC=C(NCCNC2=NC=C(C3=NC=C(C)N3)C(C4=CC=C(Cl)C=C4Cl)=N2)N=C1.[H]Cl.[H]Cl.[H]Cl
- Storage Instruction2°C to 8°C,-20°C,-80°C
- UNSPSC12352200