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Laduviglusib trihydrochloride [1782235-14-6]

HY-10182B
MedChem Express
CAS Number1782235-14-6
Product group Chemicals
Estimated Purity98.01%
Molecular Weight574.72
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Packing Size
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Overview

  • Supplier
    MedChem Express
  • Product Name
    Laduviglusib trihydrochloride [1782235-14-6]
  • Delivery Days Customer
    10
  • CAS Number
    1782235-14-6
  • Estimated Purity
    98.01%
  • Molecular Formula
    C22H21Cl5N8
  • Molecular Weight
    574.72
  • Scientific Description
    Laduviglusib (CHIR-99021) trihydrochloride is a potent and selective GSK-3alpha/beta inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib trihydrochloride shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib trihydrochloride is also a potent Wnt/beta-catenin signaling pathway activator. Laduviglusib trihydrochloride enhances mouse and human embryonic stem cells self-renewal. Laduviglusib trihydrochloride induces autophagy.
  • SMILES
    N#CC1=CC=C(NCCNC2=NC=C(C3=NC=C(C)N3)C(C4=CC=C(Cl)C=C4Cl)=N2)N=C1.[H]Cl.[H]Cl.[H]Cl
  • Storage Instruction
    2°C to 8°C,-20°C,-80°C
  • UNSPSC
    12352200