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ProductsBack/Colcemid [477-30-5]
Chemical Structure
Chemical Structure
Chemical Structure

Colcemid [477-30-5]

Research Use Only
AG-CR1-3567
AdipoGen Life Sciences
CAS Number477-30-5
DownloadMSDS
Product group Chemicals
Estimated Purity>98%
Molecular Weight371.4
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Colcemid
  • Delivery Days Customer
    10
  • ADR Class
    6.1
  • CAS Number
    477-30-5
  • Certification
    Research Use Only
  • Estimated Purity
    >98%
  • Hazard Information
    Danger,Excepted quantity
  • Molecular Formula
    C21H25NO5
  • Molecular Weight
    371.4
  • Scientific Description
    Anti-cancer compound [2, 6, 7, 10, 11, 14]. Cell synchronization agent. Used as a drug in chemotherapy by synchronizing tumor cells at metaphase, the radiosensitive stage of the cell cycle [11, 12, 14]. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation) [1, 4, 5, 14]. Inhibits mitosis during cell division at metaphase by inhibiting spindle formation [2, 5, 7, 8, 14]. Low concentrations affect microtubule dynamics and cell migration, while high concentrations promote microtubule detachment from microtubule organizing center [14]. Apoptosis inducer [9, 13]. Thrombopoietic agent [3]. - Chemical. CAS: 477-30-5. Formula: C21H25NO5. MW: 371.4. Semisynthetic from colchicine (Prod. No. AG-CN2-0048). Anti-cancer compound. Cell synchronization agent. Used as a drug in chemotherapy by synchronizing tumor cells at metaphase, the radiosensitive stage of the cell cycle. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation). Inhibits mitosis during cell division at metaphase by inhibiting spindle formation. Low concentrations affect microtubule dynamics and cell migration, while high concentrations promote microtubule detachment from microtubule organizing center. Apoptosis inducer. Thrombopoietic agent.
  • SMILES
    CNC1CCC2=C(C(OC)=C(OC)C(OC)=C2)C2=CC=C(OC)C(=O)C=C12
  • Storage Instruction
    -20°C,2°C to 8°C
  • UN Number
    UN 2811
  • UNSPSC
    12352200

References

  • Effect of colcemid on fibroblast motility: M.H. Gail & C.W. Boone; Exp. Cell Res. 65, 221 (1971)
  • Mitosis in human leukemic leukocytes during colcemid inhibition and recovery: M. McGill & B. R. Brinkley; Cancer Res. 32, 746 (1972)
  • The effects of colcemid on hematopoiesis in the mouse: P.A. Bunn Jr. et al.; J. Clin. Invest. 58, 1280 (1976)
  • Colcemid and colchicine binding to tubulin. Similarity and dissimilarity: A.C. Banerjee & B. Bhattacharyya; FEBS Lett. 99, 333 (1979)
  • Comparison of mitostatic effect, cell uptake and tubulin-binding activity on colchicine and colcemid: A.S. Serpinskaya, et al.; Biochim. Biophys. Acta 673, 86 (1981)
  • Action of demecolcine (colcemid) in the murine sarcoma 180 tumor: T. Nomura & J.E. Plager; Cancer Treat. Rep. 65, 283 (1981)
  • Colcemid effects on B16 melanoma cell progression and aberrant mitotic division: B.K. Bhuyan, et al.; J. Cell Physiol. 132, 237 (1987)
  • Colcemid and the mitotic cycle: C.L. Rieder & R.E. Palazzo; J. Cell. Sci. 102, 387 (1992)
  • Induction of apoptosis by the anti-tubulin drug colcemid: relationship of mitotic checkpoint control to the induction of apoptosis in HeLa S3 cells: S.W. Sherwood, et al.; Exp. Cell. Res. 215, 373 (1994)
  • Effects of colcemid concentration on chromosome aberration analysis in human lymphocytes: R. Kanda, et al.; J. Radiat. Res. (Tokyo) 35, 41 (1994)