Dexamethasone acetate [1177-87-3]

Catalog number: HY-14648A_1g
Brand: MedChem Express
Packing: 1 g
Other sizes: Other sizes available
Price: € 126.00
Expected delivery time: 10 days

Product specifications for - Dexamethasone acetate [1177-87-3]

Product group: Chemicals
Category: Other
CAS No.: 1177-87-3
Purity: >98%
Molecular Formula: C24H31FO6
Molecular weight: 434.50
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs that has anti-inflammatory and immunosuppressant properties. IC50 Value: 58 nM (HECM-induced eosinophil survival) [1] Target: in vitro: DEX in concentrations from 1 to 100uM did not change LDH release but exposure to 10uM and 100uM DEX for 24, 48 and 72h caused a significant reduction in cell viability and proliferation as confirmed by MTT reduction and BrdU ELISA assays, respectively [2]. Dex impaired neuron and oligodendrocyte maturation in PUFA-supplemented cells, demonstrated by the reduction of neurite lengths and oligodendrocyte sizes [3]. in vivo: The levels of IL-17, IL-6 and Tim-3 were substantially increased and the IL-10 level decreased in BALF in the asthmatic mice, which was significantly reversed by DEX treatment [4]. An IM bolus injection of DEX sodium phosphate in pigs resulted in a fast and complete absorption, with a mean maximal plasma concentration of 80.94+/-21.29ng/mL at 0.35+/-0.21h and a high absolute bioavailability of 131.06+/-26.05% [5]. Clinical trial: PANORAMA-1: Panobinostat or Placebo With Bortezomib and Dexamethasone in Patients With Relapsed Multiple Myeloma. Phase 3
Safety information: 
Additional information: 
Synonyms: HY-14648A
J Ethnopharmacol. 2021 Mar 1;267:113516. Read more