Doxorubicin (hydrochloride) [25316-40-9]

Catalog number: HY-15142_100mg
Brand: MedChem Express
Packing: 100 mg
Other sizes: Other sizes available
Price: € 120.00
Expected delivery time: 10 days
Doxorubicin hydrochloride Chemical Structure
CAS No. : 25316-40-9...

Product specifications for - Doxorubicin (hydrochloride) [25316-40-9]

Product group: Chemicals
Category: Other
CAS No.: 25316-40-9
Purity: >98%
Molecular Formula: C27H30ClNO11
Molecular weight: 579.98
Datasheet: Datasheet
  Research Use Only
UNSPSC: 12352200
Scientific information: 
Scientific info: Doxorubicin Hcl(Adriamycin) is an antibiotic agent that inhibits DNA topoisomerase II and induces DNA damage and apoptosis. IC50 Value: Target: Topo II, ADCs Toxin in vitro: Doxorubicin can block the synthesis of DNA by intercalating into the DNA strand, and inhibits DNA topoisomerase II (TOP2). Doxorubicin is most effective when cells are rapidly proliferating and expressing high levels of TOP2. Additionally, Doxorubicin can trigger apoptosis by producing ceramide (which prompts apoptosis by activating p53 or other downstream pathways such as JNK), the degradation of Akt by serine threonine proteases, the mitochondrial release of cytochrome c, increased FasL (death receptor Fas/CD95 ligand) mRNA production, and a greater production of free radicals. Doxorubicin induced G2/M checkpoint arrest are attributed to elevated cyclin G2 (CycG2) expression and phospho-modification of proteins in the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) signaling pathways. Doxorubicin inhibits AMP-activated protein kinase (AMPK), resulting in SIRT1 dysfunction, p53 accumulation, and increased cell death in mouse embryonic fibroblasts (MEFs) and cardiomyocytes, which can be further sensitized by pre-inhibition of AMPK. in vivo: Doxorubicin in combination with adenoviral MnSOD (AdMnSOD) plus 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) has the greatest effect in decreasing the volumes of MB231 tumors and prolonging survival of mice. Although its use is limited by the chronic and acute toxic side effects it produces, Doxorubicin is essential in treating breast and oesophageal carcinomas, solid tumours in childhood, osteosarcomas, Kaposi's sarcoma, soft tissue sarcomas, and Hodgkin and non-Hodgkin lymphomas.
Safety information: 
Additional information: 
Synonyms: HY-15142; Hydroxydaunorubicin hydrochloride; MedChem Express
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